The Yellow Wallpaper By Charlotte Perkins Gilman - 1926 Words

Written in 1892, Charlotte Perkins Gilman’s short story â€Å"The Yellow Wallpaper† tells the experience of a nervous woman named Jane who falls into psychosis during the â€Å"rest cure† treatment prescribed by her husband John. The rest cure admits the patient to bed rest with limited activity for the body and mind allowed; Dr. S. Weir Mitchell advocated the rest cure and is mentioned by name in the short story by Gilman who had him as her doctor (Gilman 80). During Jane’s rest cure, she is banned from creative work like writing her thoughts but finds â€Å"great relief from writing on dead paper†, even if it includes hiding her banned writings from being discovered. The one main complaint Jane has in her writings is the yellow wallpaper that surrounds the room without pattern or end and slowly grows more bothersome to Jane during her rest cure. Jane describes how the colors remind her of disgusting yellow things, how even the wallpaper smells up the rental house, and shakes by a woman within the wallpaper (Gilman 85-86). With nothing to occupy Jane’s mind the wallpaper becomes an obsession that torments her anxiety and consumes her sanity towards the end of her rest cure. Gilman experiences the same madness from her rest cure treatment as Jane in â€Å"The Yellow Wallpaper†. The horrid treatment of â€Å"rest cure† from doctor Silas Weir Mitchell led author Charlotte Perkins Gilman into writing â€Å"The Yellow Wallpaper,† sharing her experience of madness resulting from her treatment to represent theShow MoreRelatedThe Yellow Wallpaper By Charlotte Perkins Gilman885 Words   |  4 Pagesbeen a stigma around mental illness and feminism. â€Å"The Yellow Wallpaper† was written by Charlotte Perkins Gilman in the 1900’s. â€Å"The Yellow Wallpaper† has many hidden truths within the story. The story was an embellished version her own struggle with what was most likely post-partu m depression. As the story progresses, one can see that she is not receiving proper treatment for her depression and thus it is getting worse. Gilman uses the wallpaper and what she sees in it to symbolize her desire to escapeRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman846 Words   |  4 PagesHumans are flawed individuals. Although flaws can be bad, people learn and grow from the mistakes made. Charlotte Perkins Gilman’s short story, â€Å"The Yellow Wallpaper†, gives one a true look at using flaws to help one grow. Gilman gives her reader’s a glimpse into what her life would have consisted of for a period of time in her life. Women were of little importance other than to clean the house and to reproduce. This story intertwines the reality of what the lives of woman who were considered toRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman1362 Words   |  6 Pagesas freaks. In the short story â€Å"The Yellow Wallpaper† by Charlotte Perkins Gilman, both of these elements are present. Gilman did a wonderful job portraying how women are not taken seriously and how lightly mental illnesses are taken. Gilman had, too, had firsthand experience with the physician in the story. Charlotte Perkins Gilman s believes that there really was no difference in means of way of thinking between men or women is strongly. â€Å"The Yellow Wallpaper† is a short story about a woman whoRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman1547 Words   |  7 PagesCharlotte Perkins Gilman s career as a leading feminists and social activist translated into her writing as did her personal life. Gilman s treatment for her severe depression and feelings of confinement in her marriage were paralleled by the narrator in her shorty story, The Yellow Wallpaper. Charlotte Perkins Gilman was born in 1860 in Hartford, Connecticut. Her parents, Mary Fitch Perkins and Fredrick Beecher Perkins, divorced in 1869. Her dad, a distinguished librarian and magazine editorRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman2032 Words   |  9 Pagesâ€Å"The Yellow Wallpaper† by Charlotte Perkins Gilman is a poem about women facing unequal marriages, and women not being able to express themselves the way they want too. Charlotte Perkins Gilman was born in 1860, and died in 1935. This poem was written in 1892. When writing this poem, women really had no rights, they were like men’s property. So writing â€Å"The Yellow Wallpaper† during this time era, was quite shocking and altered society at the time. (Charlotte Perkins Gilman and the Feminization ofRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman904 Words   |  4 Pagescom/us/definiton/americaneglish/rest-cure?q=rest+cure). Charlotte Perkins Gilman wrote The Yellow Wallpaper as a reflection of series of events that happened in her own life. Women who fought the urge to be the typical stereotype were seen as having mental instabilities and were considered disobedient. The societal need for women to conform to the standards in the 1800s were very high. They were to cook, clean and teach their daughters how to take care of the men. Gilman grew up without her father and she vowedRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman999 Words   |  4 Pages â€Å"The Yellow Wallpaper† is a story of a woman s psychological breakdown, which is shown through an imaginative conversation with the wallpaper. The relationship between the female narrator and the wallpaper reveals the inner condition of the narrator and also symbolically shows how women are oppressed in society. The story, read through a feminist lens, reflects a woman s struggle against the patriarchal power structure. In the â€Å"The Yellow Wallpaper†, Charlotte Perkins Gilman uses the wallpaperRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman Essay1208 Words   |  5 Pagesthat wallpaper as I did?† the woman behind the pattern was an image of herself. She has been the one â€Å"stooping and creeping.† The Yellow Wallpaper was written by Charlotte Perkins Gilman. In the story, three characters are introduced, Jane (the narrator), John, and Jennie. The Yellow Wallpaper is an ironic story that takes us inside the mind and emotions of a woma n suffering a slow mental breakdown. The narrator begins to think that another woman is creeping around the room behind the wallpaper, attemptingRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman846 Words   |  4 PagesThe dignified journey of the admirable story â€Å"The Yellow Wallpaper† created by Charlotte Perkins Gilman’s, gave the thought whether or not the outcome was influenced by female oppression and feminism. Female oppression and feminist encouraged a series of women to have the freedom to oppose for their equal rights. Signified events in the story â€Å"The Yellow Wallpaper† resulted of inequality justice for women. Charlotte Perkins Gilman gave the reader different literary analysis to join the unjustifiableRead MoreThe Yellow Wallpaper By Charlotte Perkins Gilman1704 Words   |  7 PagesEscaping The Yellow Wallpaper Charlotte Perkins Gilman (1860-1935) whom is most acclaimed for her short story The Yellow Wallpaper (1891) was a women’s author that was relatively revolutionary. Gilman makes an appalling picture of captivity and confinement in the short story, outlining a semi-personal photo of a young lady experiencing the rest cure treatment by her spouse, whom in addition to being her husband was also her therapist. Gilman misused the rest cure in The Yellow Wallpaper to alarm other

Gender Objectification Of Women, Emotional Literacy And...

Analysis of Gender: Objectification of Women, Emotional Literacy and Gender Roles Introduction Gender in American society is a hot topic right now on many levels. The spotlight on how women have been portrayed in our culture now shines on the negative messages being taken to heart and embodied by our women. These are the very same images and messages being taken in by our men, to the continued detriment of our women. As a nation we have seen the blossoming of the darker, destructive aspects of masculinity, with the very people elected to run our country leading the charge, reducing many of our national ideals to their lowest common denominator instead of exemplifying a more enlightened ideology for our future. Society had just†¦show more content†¦Women are portrayed as objects, something to be owned, used and thrown away, with their primary value based on the sexual gratification of men (Wright Tokunaga, 2016). Women in American society are expected to conform to the stand ards of beauty outlined in advertising, even though those images are unnatural and enhanced through Photoshop. Social media shows videos of how the photo of a real model, with all her natural beauty and flaws, is manipulated; the flaws erased, eyes unrealistically enlarged, thighs reduced and cellulite smoothed away. The direct effect of objectification on women in our society has already been linked to an increase in eating disorders such as anorexia and bulimia. The images of women in advertising are role models real women can never live up to, and these unrealistic ideals have become the standard by which men measure women. Watson, Marszalek, Dispenza and Davids (2015) conducted a study on the effect of objectification on African American and White women in an attempt to compare/contrast the experiences of objectification on women, concentrating on two extremes of the racial dynamic in our society. The results of the research showed the increase in anxiety, depression and psycho logical distress, including fear of assault/rape, reported by the women included in the study in response to the continual sexual harassment these women experienced. It also noted that African American women experienced these effects at a much higherShow MoreRelated Gender Roles in the Media Essay3973 Words   |  16 Pageswrapped in a pink or blue blanket, a childs gender is unmistakable. From this point on, they will continuously be bombarded with the socialization into their gender by many sources. One of the main sources of this socialization is media, more specifically television. The purpose of this paper is to describe gender roles and stereotypes, and to take a closer look at how the medias representation and portrayal of males and females affects children. Gender differences are the sets of attributesRead MoreEssay about Dehumanization of Humanity1341 Words   |  6 Pages While most slaves experienced the dehumanization that slavery thrust upon them, every slave experienced it in a unique and individual fashion. For Fredrick Douglass the dehumanization occurred in a physical fashion, whereas Harriet Jacobs’s objectification was through mental oppression. Fredrick Douglass always was a slave since the day he was born. While his entrapment began in a somewhat mild way with basic chores and tasks being assigned to him, he had the responsibilities of manhood thrustRead MoreImpact of Print Media on Society10439 Words   |  42 PagesTHE EFFECTIVENESS OF THE DOVE EVOLUTION FILM AS A ONE-SHOT MEDIA LITERACY TREATMENT by DANIEL AARON WHEELER A.A. Alabama Christian College 1979 B.A. Western Illinois University 1989 M.A. University of Alabama 1994 A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Department of Educational Studies in the College of Education at the University of Central Florida Orlando, Florida Spring Term 2009 Major Professors: Cynthia J. HutchinsonRead MoreMass Medi A Positive Side And A Negative Side3367 Words   |  14 Pageschildhood educational intervention (cited in references).† These positive outcomes include learning about the world which includes health and safety, social reasoning and attitudes, and also cognitive literacy and numeracy. â€Å"The significant, positive effects of cognitive, learning, and socio-emotional outcomes observed in the current meta-analysis represent real educational benefits for the millions of preschool-age children around the world who visit ‘Sesame Street’ via their televisions,† says Mares

Listing Rules and Role of Australians Security and Investment Commissi

Question: Discuss about the Listing Rules and Role of Australians Security and Investment Commission. Answer: Introduction Communication and leadership are the key factors for running a business effectively. Businessmen have to incorporate a legal entity to run their business in determined approach. Companies have to get their shares listed on stock exchange in order to raise capital from the general public over the time with the increasing ramification of economic working conditions. Leadership and communication are two aspects which are required to be absorbed by top management for proper business functioning. However, communication skills are the sub part of leadership. In this report various communication and leadership intents have been taken into consideration for business functioning of organization. In the starting of this report investigation and procedure to incorporate small propriety company have been discussed. Afterward, role of Australian security exchange in society has been evaluated. Then listing rules and regulations that are applicable in Australian company have been read with corpora te laws. In the end, the most imperative factor of role played by Australian security and investment commission for regulating the behavior of companies in their business functioning are discussed. A leader of organization has to evaluate all the laws and regulation in order to avoid possible penalties (Kang Gray, 2013). Investigate the procedure and framework which is required to be followed under the corporation Act 2001 to incorporate small proprietary company. Small Propriety Company In Australia, a proprietary company is defined under section 45(1) of the corporation act 2001. This is a company which satisfies following two conditions subject to the otherwise provided in the corporation act 2001. This company is ideally incorporated with a view to start a business with separate legal entity. However, businessman chooses to incorporate small propriety company when he wants to start new business with low capital and with less complexity in his business functioning (Dwyer Kotey, 2015). The consolidated amount of revenue for the financial years of the companies it controls is below $ 25 million. The value of consolidate assets of all the companies it controls is less than $ 12.5 million. Number of employees of the company including the company it controls has less than 50 employees. There are two options to incorporate a small proprietary company as per corporation act 2001. First we can contact private services providers or lodge a paper directly with AISC. In the second option a form- 201- (application for registration of company) would be filled and lodge it with Australian security and investment commission. Then ASIC will give ACN number accompanied with certificate of registration which will be unique to small proprietary company. However, while incorporation of small proprietary company businessmen needs to follow all the guidelines given in information sheet 1 (INFO 61). Role of Australian stock exchange in society Society is accompanied with stakeholders of the company. Role of stock exchange are varied and highly important for the economic development of country. Australian stock exchange is an Australian public company that operates Australian stock exchange where all the shares of listed Australian companies are listed. The Australian security and investment commission have responsibility for the supervision for the real time trading of Australian domestic licensed markets (Daneshgar Wang, 2007). The fundamental role of ASX is to provide an effective way for the business man to raise capital form the market. However, ASX works for the best interest of the investors and protect their rights from unethical behavior of organizations. Ideally ASX assists investors to buy and sell their securities and scriptures in secondary market so that they could increase the value of their investment. The main role of ASX is to list the securities of the companies and provide a proper surveillance of the listed company. It also facilities secondary market for the investors to buy and sell the securities issued by the listed company. In addition, ASX imposes straighten rules for the companies to get their shares listed on exchanges which ultimately results into better corporate governance simultaneously. It has also observed that Australian stock exchange provides stock indexes which could be used as true indicators for the economic growth of Australian economy. Australian stock exchange is ma in body to manage risk of market to curb insider trading (buying and selling of shares with the help of confidential information). In simple words it would be said that Australian stock exchange provides a bridge to investors and companies to contact each other. Priority is established to provide all the possible safeguards to protect the best interest of investors (Chiappini, 2011). ASX listing rules and procedure to be followed by the company to list their share listed on Australian stock exchange ASX regulates the offers of securities by companies in Australia and certain associated matters such as trading of securities, insider trading, market misconduct and pre prospectus advertisement. In addition to this, ASX issues various listing rules and regulation which assists in better corporate governance of the company on continues basis. The listing rules set out the specific requirements that an organizations has to meet to make effective compliance in their business functioning. As per the Australian listing rules, company must satisfy minimum admission criteria including structuring and number of employees given as below to be eligible to list on ASX, (Bessler, et., al., 2012). The Companies which want to list their security has to maintain 400 employees and $ 2000 and unrelated party would hold 50 % of security. In case of company which is already listed on a foreign exchange can list on ASX. In this case the listing requirement of ASX would be followed by the company and foreign listing rules will be exempted. Those companies which are about to come up with Initial public offer in the market are tend to list their shares on stock exchange. However, there are following advisors who will help companies to list their shares listed on exchange (Wilkinson, 2014). There are following obligation on the companies to get their shares listed on the stock exchange. Each listed companies must notify ASX immediately for their shares listed after complying all the listing rules and regulations. Once company gets its shares listed on the stock exchange then it has to comply with the entire listing discourse requirement on the consistent basis. In addition, ASX also resolves all the possible grievances and problems of employees in effective manner. (Lewis, 2014). Financial reporting is required on a half yearly and annual basis in Australia. However, companies without track record need to file quarterly cash flow statement. It is also observed that mining and Oil companies are required to file quarterly reports on their activities of investment with the ASX stock exchange (Charest, et., al., 2014). In case of Dual listing problem of company it would be observed that company should comply with both rules if shares are issued on domestic and international level as well. However, in case of issue of shares in Australia, company only needs to comply with Australian listing rules and regulations. ASX also requires listed companies to take shareholders approval in their annual general meeting before issue of shares in the general public (Andersen Tourani, 2013). Key factors in ensuing a successful listing Identify whether an IPO is the right option for the company if so then evaluate whether ASX is the most appropriate stock exchange for the organization. Preparation of prospectus and other offer letters containing all the required details of the company for the investors. Prepare action plan to list its security on the appropriate stock exchange in context with investors inclination with the companys offering. Preparation of due diligence report in order to make investors vigilant about the company. Complying with the entire listing disclosure requirement. Appointment of compliance officer for complying with all laws and regulation of listing rules (Kang Gray, 2013). In addition to this, company has to comply with the entire listing requirement such as having minimum capital requirement, minimum number of employees partition of unrelated party investment in share capital of the company. Role played by the Australian security and investment commission It is an independent Australian government body that act as Australians corporate regulators. The main role of Australian security and investment commission is to regulate and enforce all the laws and regulation on the registered company in order to protect Australian consumers, investors and other creditors in effective manner. The main aim of ASIC is to promote efficiency, honesty and fair business functioning of companies in Australia. It is also known as financial service regulator for the wellbeing of Australias economic reputation and ensuring that Australian security and financial market are providing true and transparent values to its investors. Australian security and investment commission is also responsible for the supervision of operators of financial markets, operators of clearing and settlement facilities of market participants. Australian security and investment commission undertakes all the regulatory enforcement powers, issue licenses and monitors ethical working conditions of companies. It ensures that promoters and management department of companies are providing effective business operation to their clients through the Australian financial services licensing system which includes (Guseva, 2013). Make rules aimed at ensuring the integrity of financial market Incorporate prosecution Seek civil penalties form the court against wrong doers Issue infringement notices to companies which have committed default in their business functioning. Indulge in suspected breaches of the laws and ask companies to justify the reasons of doing so in proper manner (Dwyer Kotey, 2015). Ideally Australian security and investment commission is concerned with protecting the interest of investors, creditors and clients from the business functioning of organization in the market. It is observed that if company holds the license issued by the Australian security and investment commission then it would be considered as highly ethical company in terms of its offering (McGrath, 2013). ASIC governance structure The commission that governs ASIC is comprised of chairperson, deputy chairpersons and between one and six other members. It meets on monthly basis to discuss all the required matters on the financial services provided by the organizations in Australian market. However, it does not have set code of conduct for its functioning. The government expects that ASIC will comply with government regulatory impact analysis requirement for regulatory proposals, The Main role played by Australian security and investment commission It has observed that Australian security and investment commission issues license which reflects that company is complying with all the required regulations and laws (with a view to increase the transparency in their business functioning). In addition, it contributes to Australian economic reputation and other wellbeing of people of Australia by ensuring that Australians financial market is reflecting all the true and fair view with the transparent policies and frameworks. Conclusion In this report there are various topics e.g. incorporation of small company, role played by Australian security and investment commission in Australian market and how legal framework related with the listing rules could be followed for the better transparency of organization. It is observed that the main purpose of Australian stock exchange is to protect the interest of investors and helps them to manage their marketing risk accordingly. Throughout the time with the increasing ramification Australian security and investment commission and other regulatory bodies have strengthen listing polices and laws for the better protection of interest of investors. Now in the end it would be said that companies which want to get their shares listed on stock exchange has to comply with all the listing rules and regulation otherwise it will has to face high amount of penalty. References Andersen, A., Gilbert, A. Tourani-Rad, A. 2013, "Breach of continuous disclosure in Australia",JASSA,, no. 4, pp. 21-26. Bessler, W., Kaen, F.R., Kurmann, P. Zimmermann, J. 2012, "The listing and delisting of German firms on NYSE and NASDAQ: Were there any benefits?",Journal of International Financial Markets, Institutions and Money,vol. 22, no. 4, pp. 1024-1053. Charest, G., Cosset, J., Marhfor, A. M'Zali, B. 2014, "Financing constraints and US cross?listing",Canadian Journal of Administrative Sciences / Revue Canadienne des Sciences de l'Administration,vol. 31, no. 3, pp. 160-174. Daneshgar, F. Wang, J. 2007, "Validation of the awareness net model for the Australian security investment processes",Knowledge-Based Systems,vol. 20, no. 8, pp. 736-744. Dwyer, B. Kotey, B. 2015, "Financing SME Growth: The Role of the National Stock Exchange of Australia and Business Advisors: Financing SME Growth",Australian Accounting Review,vol. 25, no. 2, pp. 114-123. Guseva, Y. 2013, "Cross-listings and the new world of international capital: another look at the efficiency and extraterritoriality of securities law",Georgetown Journal of International Law,vol. 44, no. 2, pp. 459. Kang, H. Gray, S.J. 2013, "Segment Reporting Practices in Australia: Has IFRS 8 Made a Difference?",Australian Accounting Review,vol. 23, no. 3, pp. 232-243 Lewis, K. 2014, "ASX releases final version of listing rule changes",Governance Directions,vol. 66, no. 6, pp. 329. McGrath, M. 2013, "Guidance Note 8 Continuous Disclosure: Listing Rules 3.1-3.1B - any new challenges?",Keeping Good Companies,vol. 65, no. 4, pp. 202-203. Starr, M. 2011, "Regulating ASX - the regulation of listing, trading, clearing and settlement businesses",Keeping Good Companies,vol. 63, no. 5, pp. 270. Warren, K. Dimovski, B. 2012, "The direct costs of raising equity capital by renounceable rights issues in Australia",JASSA,, no. 2, pp. 14-19. Wilkinson, S. 2014, "Key changes to proposed ASX listing rules",Governance Directions,vol. 66, no. 4, pp. 223-225.

Thinking Critically Simulation

Overview of the Simulation A thinking critical simulation is one of the most effective tools to be used in order to evaluate the effectiveness of the three main decision-making steps which are framing the problem itself, making the decision, and, finally, evaluating the decision offered. In this paper, Credenhill business is taken into consideration; the company developed a new program, called Thorough-Cred that aims at selecting the best managers. Advertising We will write a custom essay sample on Thinking Critically Simulation specifically for you for only $16.05 $11/page Learn More The chosen tool provides all managers of the company with a chance to demonstrate their skills and run the company accordingly. Linda James offers to investigate the electronics store that has been facing a number of problems during the last eight weeks, and it is necessary to make use of the appropriate thinking skills and tools to overcome the challenges. In general, the identification of the most crucial problems such as wrong product mix, WAN and variable pay issues is necessary. As soon as the identification of the problems is made, problem resolution begins. The budget is limited, and this is why it is better to improve sales considering the conditions given. One of the possible suggestions is to focus on workers’ dissatisfaction. The evaluation of such decision proves that the workers will be better stimulated and promote work as the possibility to get the bonus and attract attention of more customers. Summary of the Simulation Question One The tools which are used in this case are chosen on the basis of the investigations conducted by Prensky (2010); they are brainstorming as the possibility to come up with a variety of decisions on the same problem, intuition as a chance to evaluate what idea is more effective under the created conditions, group think as an opportunity to consider several perspectives of the same case, and importance of weighting in order to debate the reasons, conditions, and the solutions offered (Open University Course Team, 2008). The peculiar feature of the techniques used is that all of them provide the managers with a chance to underline the main problems and evaluate as many necessary aspects as possible. It is not enough to define the problem but also think about the methods to benefit from its solution. Question Two The techniques and tools used in this case assist with the evaluation of the decision-making process and outcomes in a variety of ways. First, the techniques provide a logical approach to solve the problems so that each manager is able to make use of his/her skills and knowledge. Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Second, each problem is properly weighted by all representatives of the group, and the chances to introduce appropriate solution are increased. And finall y, group think consensus helps to clarify properly which aspects need some improvements and which outcomes are better to expect. Question Three The outcomes which are reached in the simulation are more or less expected. First, a new pay plan has to be implemented in order to improve the financial conditions of the company and encourage the workers to achieve better results. Another significant decision is based on the product mix that has to be reoriented taking into consideration the fact that a number of Internet products and multimedia offers are in demand. In general, as soon as the techniques are implemented, and the steps for improvement are taken, the outcome of the activities will positively influence the development of the company, employees’ attitude to work, and customers’ interests in the production offered. Reference List Open University Course Team. (2008). Thinking critically. Milton Keynes: Open University Worldwide Ltd. Prensky, M. (2010). Teaching di gital natives: Partnering for real learning. Thousand Oaks: Corwin Press. This essay on Thinking Critically Simulation was written and submitted by user Wesley Cherry to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Selectively Permeable Definition and Examples

Selectively Permeable Definition and Examples Selectively permeable means a membrane allows the passage of some molecules  or ions and inhibits the passage of others. The capacity to filter molecular transport in this manner is called selective permeability. Selective Permeability Versus Semipermeability Both semipermeable membranes and selectively permeable membranes regulate the transport of materials so that some particles pass through while others cant cross. Some texts use terns selectively permeable and semipermeable interchangeably, but they dont mean exactly the same thing. A semipermeable membrane is like a filter that allows particles to pass or not according to size, solubility, electrical charge, or other chemical or physical property. The passive transport processes of osmosis and diffusion permit transport across semipermeable membranes. A selectively permeable membrane chooses which molecules are allowed to pass based on specific criteria (e.g., molecular geometry). This facilitated or active transport  may require energy. Semipermeability can apply to both natural and synthetic materials. In addition to membranes, fibers may also be semipermeable. While selective permeability generally refers to polymers, other materials may be considered to be semipermeable. For example, a window screen is a semipermeable barrier that permits the flow of air but limits the transit of insects. Example of a Selectively Permeable Membrane The lipid bilayer of the cell membrane is an excellent example of a membrane which is both semipermeable and selectively permeable. Phospholipids in the bilayer are arranged such that the hydrophilic phosphate heads of each molecule are on the surface, exposed to the aqueous or watery environment inside and outside of cells. The hydrophobic fatty acid tails are hidden inside the membrane. The phospholipid arrangement makes the bilayer semipermeable. It allows the passage of small, uncharged solutes. Small lipid-soluble molecules can pass through the hydrophilic core of the layer, such hormones, and fat-soluble vitamins. Water passes through the semipermeable membrane via osmosis. Molecules of oxygen and carbon dioxide pass through the membrane via diffusion. However, polar molecules cannot easily pass through the lipid bilayer. They can reach the hydrophobic surface, but cant pass through the lipid layer to the other side of the membrane. Small ions face a similar problem because of their electrical charge. This is where selective permeability comes into play. Transmembrane proteins form channels that permit the passage of sodium, calcium, potassium, and chloride ions. Polar molecules can bind to surface proteins, causing a change in the configuration of the surface  and gaining them passage. Transport proteins move molecules and ions via facilitated diffusion, which does not require energy. Large molecules generally dont cross the lipid bilayer. There are special exceptions. In some cases, integral membrane proteins allow passage. In other cases, active transport is required. Here, energy is supplied in the form of adenosine triphosphate (ATP) for vesicular transport. A lipid bilayer vesicle forms around the large particle and fuses with the plasma membrane to either allow the molecule into or out of a cell. In exocytosis, the contents of the vesicle open to the outside of the cell membrane. In endocytosis, a large particle is taken into the cell. In addition to the cellular membrane, another example of a selectively permeable membrane is the inner membrane of an egg.

How To Write An Essay About Perfect Boss, with Outline

How To Write An Essay About Perfect Boss, with Outline How to Write an Essay about Perfect Boss (Writing Guide) How to start an essay about perfect boss How to write thesis for an essay  about perfect boss How to write body pargraphs for an essay about perfect boss How to conclude an essay about  perfect boss Outline example Topic Actuality Essay writing takes into consideration a few basics that make a paper stand out. In this case, the topic to focus on is The Perfect Boss. It deals with the characteristics typically associated with a perfect boss that is, an employees superior at the place of work. It elaborates on the behaviors of a boss whom an employee or junior person can want to emulate. A boss is someone who portrays power and influence. The topic and general paper should paint or portray this fact effectively. How to Start an Essay about Perfect Boss To write an essay about a perfect boss, one will follow a few steps. The author will first define what a boss is. There are different types of bosses at different places of work. The definition has to capture the fact that a boss mainly relates to the place of work. The introduction should also clarify that no boss is perfect, just as no human being is perfect. All employers have faults. However, a perfect boss is one who meets most of the expected behaviors of a good manager or employer. The expectations are to be pointed out in the subsequent paragraphs. How to Write Thesis for an Essay about Perfect Boss Given that the topic is already identified and the extent of the content determined, the next thing one has to do is identify and clearly point out the thesis statement. A thesis statement, the last sentence found in the introductory paragraph, is a short statement that illustrates the position that the writer intends to pass across. The thesis statement should give the reader a hint about the characteristics of a perfect boss. For instance, the thesis statement should summarize the main features of a perfect boss such as honesty, being a role model for employees, hardworking, understanding, smart, among others. Alternatively, the thesis statement can also highlight the summary of what a perfect boss should be. For instance, it can read, a perfect boss will not only be hard working, strict, and act as a role model to employees, but will also show deep and sincere concern for employees. How to Write Body Paragraphs for an Essay about Perfect Boss The body of the essay is to be about three paragraphs. The first paragraph will enumerate a few examples of bosses who have been acknowledged by employees as perfect bosses. Examples should be drawn from a variety of sources, industries, and sectors. For instance, the essay will mention globally recognized and feted managers and directors. Typical examples of perfect bosses to be emphasized include Mark Zuckerberg, the Chief Executive Officer of Facebook, among many others. The first paragraph can also recognize less known, but revolutionary individuals who have played a leading role in the success of their industries and sectors through role modeling. The second paragraph should elaborate the fact that a boss is a manager hence his or her management style determines whether or not he becomes a perfect boss. It will draw attention to the main features of an employer or manager who can be considered a perfect boss. Some of the key features to be pointed out include leadership by example, where the boss sets high ethical standards and follows established rules and norms, and motivates employees to follow the same rule. At this point, the essay should point out how the leaders behavior and that of employees relate. Another characteristic can include effective communication. The writer should elaborate that an effective boss communicates in a timely and clear manner. Transparency, valuing employees, deep knowledge, respect, and sensitivity are other aspects that can be discussed in detail. The essay should also accentuate that a perfect boss recognizes the effort and makes the employees feel appreciated. Positive reinforcement works well on employees and encourages them to continue with good performance.   The fact that a perfect boss gives feedback should also be underscored. In this regard, the essay should state that feedback should be prompt and should be given with a positive attitude. It should be encouraging, and meant to correct rather than rebuke. A great boss, the essay should note, has to sit down with employees and discuss with them. Then he or she has to set clear expectations and motivate employees to attain the expectations. The third paragraph can highlight how the relationship between employees and their boss directly affects the performance of an organization. It will also state the fact that perfect bosses are loved by employees, they are self-motivated, and they yield results. The last part of the third paragraph will explain that a perfect boss inspires other bosses or managers at similar or higher levels to emulate him or her. How to conclude an essay about perfect boss A perfect essay is one with a short but clear conclusion that reiterates the features of a perfect boss. The concluding paragraph will also note the link between the performance of an organization and the management style. Outline Sample Introduction What is a perfect boss? Thesis statement   Nobody is perfect Body Examples of perfect bosses Effect of management styles Features of perfect bosses Impact of the relationship between employees and bosses on performance Conclusion Reiteration of main ideas

The Desighn evenet managment Assignment Example | Topics and Well Written Essays - 1500 words

The Desighn evenet managment - Assignment Example Organization of events strongly affects society as a whole. In some countries, this is a serious industry, bringing the state many billions in taxes. You can use it to attract a lot of tourists (such as carnivals in Rio de Janeiro or Venice is visited by hundreds of thousands of people), it becomes a significant source of income for local budgets. Conferences and exhibitions helps the emergence of business contacts and thus spur economic development. has long been an integral part of other economic sectors: hospitality, tourism, show business; some of the functions on the organization of activities was assigned to the sales offices, professional associations (Supovitz, 2005, p.45). This hindered the development of event-management as a distinct form of activity. Now in organizing activities were professional associations, there are specialized literature, certification programs in this area can get a higher education. Gradually the organization of events is becoming recognized industry with its technology, market players, legends and traditions. One of the factors that affect the strategic decision-making is opportunity cost. This is because when someone makes a choice, they will lose the chance of making another choice. For instance if a company decides to make advertisement on the radio, they may not have the opportunity of making another advertisement on the television because of budgetary restrictions. If a company asks the sales staff to look for new clients, they may as well forget about serving the existing customers (Boag & Cuskelly, 2011, p.67). Opportunity cost also affected the final event design pitch because it was the best option so far. Another factor that affects strategic decision-making is the effect on resources. When companies compute their profit benefit from probable decision, they must also consider the general impact on production, human resources, sales and the staff. If a certain product within the

Employment Law Essay Example | Topics and Well Written Essays - 750 words

Employment Law - Essay Example Summary Based on the information availed from this organization we get to know that the employer does not have a plan to deal with employees with different conditions. As a result, the employer must implement certain recommendations in line with organizational policy and management. One of the requirements that should be implemented is that the employee with AIDS should be recognized as disabled. Since according to the ADA act, disability cases are assessed on a case to case basis and this should include the employee suffering from AIDS. As a recommendation the employee suffering from AIDS should be accommodated according to the provisions of the ADA act (Goren, 2010). Moreover, the employer should identify with its employees that discrimination is not allowed within the workplace. As a result, the employer in this case should adhere to the provisions of the ADA and not to conduct HIV/AIDS testing at the workplace currently or in the future. In the process of preventing job disruptio n, the employer should come up with a strict adherence policy that allows all co-workers to work together irrespective of their medical condition (Goren, 2010). Apart from these recommendations, the employer in this case should come up with organizational policies that are meant to deal with these issues. One of the policy implementation points is to come up with a policy that allows for hiring of all kinds of employees and implementation of the ADA act. The employer should also implement a policy that allows all employees to learn all laws and policies that deal with workplace employment. This would assist the company to implement policies concerning disability within the company. Moreover, the company should come with a policy whereby co-workers are empowered with education concerning illnesses and disabilities. This policy will enable company employees to understand various issues concerning disabilities and make them more tolerant in interacting with either ill or disable patien ts (Blanck, 2009). The implementation of a non-discrimination policy for employees will assist in boosting the work and make it easy for supervisors to work with other employees. A non-discrimination policy will also greatly assist employees and the employer in respecting the rights of all workers in the wider scheme of implementing equal right as envisaged in different laws and regulations. The best plan to deal with these issues that have arisen in the workplace is to make use of employee training. The training plan will look into ways of ensuring scientific information is disseminated in the office and employees do not necessarily stigmatize other workers. The training plan will focus of risk assessment at the office and how to control exposure unto other employees in the company (Goren, 2010). Moreover, training should be provided on how to handle employees with AIDS in terms of work assignments and proper working conditions. Most AIDS afflicted individuals suffer greatly from s tigma and thus training will create an easy atmosphere of acceptance and work continuation (Blanck, 2009). Above all the training program is supposed to assure AIDS afflicted employees are guaranteed of work continuation and rights like all other employees. Training of employees on the risks, facts and information concerning AIDS gives a better

Championship Manager Essay Example for Free

Championship Manager Essay Paul and Mark started work on Championship Manager 97/98 in early 1997. One of the greatest quotes ever came from this Oh thisll be easy itll only take a couple of weeks, said Paul, the eternal optimist. It took a solid ten months to get it together and released and that was just the English language version. The Championship Manager 2 engine was brought to its outer limits as nine leagues were combined with the possibility of running three simultaneously almost every part of the game needed to be modified and many improvements were made. A database of some 20000 players and 2500 teams was put together with researchers helping out from all corners of the globe. This final version of Championship Manager 2, released 31st October 1997 at an update price, went straight to number one of the all formats chart and remained in the top 20 for many many months. In the meantime, Oliver, who had taken a well earned rest after 18 months solid work on Championship Manager 2, started to conceive the first ideas for Championship Manager 3. The game would once again be totally re-written. In March 1997, Oliver and new staff member Marc Vaughan launched themselves into the Championship Manager 3 project. After a lengthy three months of interviewing, the right people were found to work on Championship Manager 3. With the team assembled, work on Championship Manager 3 steamed ahead and all involved worked hard to make it into a great game. The game was (finally) released on March 26th 1999 and made history as it was the fastest selling PC Game in the UK of all time shifting over 55,000 units in its first. Championship Manager 3 continued to sell well staying at the top spot of the all formats for 3 weeks and has been top of the PC charts for 11 weeks in total since release. Three foreign language versions of Championship Manager 3 were released in May 1999. The languages included were Italian, French and Portuguese and has proved popular in all these countries as well as all the other countries where it has been distributed.

Essay --

Financiering van de Pleegzorg; De gehele Jeugdzorg, waar Jeugdhulp Friesland en dus Pleegzorg onder valt wordt gesubsidieerd door de overheid. Dit valt onder de gezondheidszorg, per deel van Jeugdhulp is er een budget die wordt ingezet om iedereen te helpen. Als voorbeeld van een activiteit heb ik de reiskostenvergoeding van stagiaires genomen, stagiaires kunnen de gemaakte kosten declareren bij de organisatie. Deze prijs is opgebouwd uit de gemaakte kilometers en welke prijs daaraan verbonden zit. Hoe je reist is ook van invloed op de prijs, als je week-ov hebt krijg je niet betaald omdat jijzelf dan gratis kan reizen. Ieder pleeggezin ontvangt pleegoudervergoeding, deze vergoeding is maandelijks en is bedoeld voor het kind. Hiervan moeten ouders dingen als kleding en bijvoorbeeld slaapspullen. De vergoeding hangt af van de leeftijd van het kind, hieronder is een tabel bijgevoegd waarin de basisbedragen voor elke leeftijdscategorie zijn omschreven. Basisbedragen van de pleegzorg per jeugdige per 1 januari 2013. Leeftijdscategorie Bedrag per maand/per dag 0 t/m 8 jaar â‚ ¬ 532/17,50 9 t/m 11 jaar â‚ ¬ 538/17,70 12 t/m 15 jaar â‚ ¬ 586/19,28 16 t/m 17 jaar â‚ ¬ 647/21,28 18 jaar en ouder â‚ ¬ 654/21,51 (Pleegzorg Nederland, 2013) Privacy: De privacyregels van Jeugdhulp Friesland staan genoteerd onder de volgende categorieà «n: ï  ¶ Informatie verzamelen en vastleggen ï  ¶ Het recht om gegevens in te zien ï  ¶ Het uitgeven van informatie aan andere personen ï  ¶ Het bewaren en vernietigen van gegevens Informatie verzamelen en vastleggen: Alle informatie over een clià «nt wordt vastgelegd in een dossier, in dit dossier staan alle standaardgegevens zoals naam, adres en geboortedatum. De informatie die bij Pleegzorg binnenkomt is afkomstig van ouders/verzorgers ... ...eegzorg bevorderen en in de belangen van pleegouders en –kinderen voorzien. (Jeugdhulp Friesland, 2014) Ook heb je de Nederlandse Vereniging voor Pleeggezinnen (NVP), de NVP is een landelijke, onafhankelijke vereniging van en voor pleegouders. De NVP zet zich in voor de belangen van pleegzorg, ze willen de kwaliteit van pleegzorg in Nederland verbeteren. Dit doen ze door middel van ondersteuning, advies en belangenbehartiging voor de pleeggezinnen. (Jeugdhulp Friesland, 2014) Alle partijen binnen Jeugdhulp Friesland communiceren met elkaar, de Raad van Bestuur staat bovenaan en pleegt overleg met de Controller en de Regiodirecteur. Alles wat naar de medewerkers moet worden doorgestuurd wordt door de Regiodirecteur geregeld, deze zorgt ervoor dat de wensen van de Raad van Bestuur door gegeven worden aan de medewerkers. Voor een communicatieoverzicht: Zie bijlage

Ch 9 Criminal Justice Administration

1)What factors contribute to the correctional populations? What impact do drug laws have on them? a. Truth-in-sentencing laws have contributed to the increase as well as failure to rehabilitate. The increase and crack down on drug related laws have contributed a significant portion of the population. 2)What are some of the major administrative positions within a prison system? a. Some of the major administrative positions are prison director, public affairs coordinator, legislative liason, legal advisors, internal affairs representative, health care professionals, correctional program professionals, and human management. )How do supermax prisons operate differently from other prisons? What concearns have been raised concerning the alleged effects on inmates, constitutionality, and public safety. a. Supermax prisons operate differently in the way they have to secure the prison and prisoner, and house them in solitary cells. Concearns that have been raised are things like the condition of confinement, there is no safety cushion provided these criminals escape, psychological harm from the way they are housed, and medical conditions. )What are at least five of the major U. S. Supreme Court decisions affording rights to prisoners? a. Ruffun v. Commonweath, Turner v. Safley, Cooper V. Pate, Johnson V. Avery, and Bounds V. Smith are all cases affording rights to prisoners. 5) When and how did such decisions serve to end the hands-off doctrine? a. They started in 1871 and they served to end the doctrine by proving that inmates should not entirely be derived from the constitution. )What is a direct supervision jail, and how does it differ in the design and function from traditional jails? a. A direct supervision jail is a new face on the old way of jails. It differs by physical environment, separating officer from inmate, allowing officers to have a direct line of sight, and softer furniture. 7)Why was the Prison Litigation Reform Act enacted, and has it made an impact? a. It was enacted to provide resoutions for prison condition lawsuits and discourage abuse.It has made an impact by reducing inmate petitions. 8)In what major ways do jails differ from prisons in their organization and administration? Assist with inmate reentry back into the community? a. They differ mainly through who looks over them. Jails serve as agaents of change and have goals for assisting in reentry. 9)What are the primary functions of a jail administrator? a. They are law enforcers. 10)What are the advantages accrue to a corrections facility if it is accreditited? a.Advantages are having state of the art procedure, improving morale and professionalism and much more. 11)What are the various types of probation systems administered in the united states? Describe each. a. Juvenile which monitors juveniles on state municipal or county level, Municipal which is independent and is administered by the lower courts, county which functions under state law, state which is centralized and provides service throughout the state, state combined which is both probation and parole, and federal which is administered by the federal courts. 2)Should Probation services be placed within the judicial or executive branch of government? Defend your answer a. They should be placed with executive because they are in charge of carrying out the laws have to see who follows them or not. 13)What are the two basic models of parole administration? a. The two basic models of parole administration are the independent model and the consolidated model.

The Caused and Effects of Lehman Brothers Bankruptcy

The caused and effects of Lehman Brothers bankruptcy. ? Lehman Brothers was founded in 1850 and it is a diversified investment bank provided financial services for global companies, institutions, governments and investors. Lehman Brothers was one of the most powerful stock and bond underwriters and dealers in the world, and it also as the fourth largest investment bank in the United States before. Because of widely recognized to Lehman’s operational capacity, the company had many world-renowned companies as its customer base such as Dell, Fujitsu, IBM, Intel, Philip Morris, Shell and Wal-Mart [1].Lehman Brothers had faced four collapses before it bankruptcy, one was the stock market crash of 1929, second it had interest rate loss of $6. 7 million in 1973, and then because of Lehman’s internal conflict led to be merger and acquisitions by American Express in 1984, and last one was shortage of funds in 1994. Richard Fuld as Lehman’s CEO from 1993, he led to Lehman Brothers grow up and avoid those four collapses. Even Lehman Brothers was turned the corner in these four collapses; it still declared bankruptcy as a result of $613 billion total debt in 2008 [7].Lehman Brothers went to collapse make lots of impacts on financial markets, the most important reason caused Lehman bankruptcy is under the subprime mortgage crisis and complex financial markets. Before the subprime mortgage crisis of 2007, the U. S. real estate market over the leveraged financing and oil price was increase rapidly, many people in the excessive lending. However, Lehman Brothers had continued business of mortgage bond until the outbreak of subprime mortgage crisis in 2006, Lehman’s asset management, economic services, mergers and securities underwriting business accounted for Lehman's operating income of 40% [2].In 2008, because the subprime mortgage crisis spread to Lehman Brothers, the company suffered a serious hit from the financial losses and caused that stock p rice fell to only a few dollars. In September 2008, the Lehman Brother’s CEO Dick Fuld had experienced the most painful financial crisis in the history of the United States and the company went bankrupt. The Lehman Brothers which had experienced 158 years history toward to end [1]. Also, the collapse of Lehman Brothers brought an unprecedented shock wave for financial market and investment banking. The terrorist attack on 2001, September 11 led to conomic downturn and the stock market depressed, the Federal Reserve decided to continue kept low interest rate to ensure the most of enterprises and publics can achieve loans easier [9]. Due to the public would had more money to be used for mortgages and other spending, Lehman Brother seized the opportunity to develop its business so that Lehman’s profits growth quickly in the second half of 2002. Lehman Brothers’ sales revenue of subprime mortgage raised double of profits in both years 2004 and 2005 [3]. And Lehmanâ €™s present value of subprime mortgage CDO (collateralized debt obligations) investment reached up to $80 billion [5].Lehman Brothers issued two mortgage bonds companies in the United States are BNC and Aurora. These two branches of mortgage bonds and purchased from other companies constituted the CDO package. The worth of CDO could be about hundreds of millions and even billions of dollars to divide for sale to investors around the world. The interest rate of CDO is much higher than the national bonds in the United States and other investments, so Lehman Brother took advantage of sale these bonds to gained large profits. After that, the public began to worried more about future develop of CDOs from Lehman Brothers and other companies.Then, Lehman Brothers shut down one of the mortgage bonds company BNC because of huge losses and this caused the public’s panic of the credit crunch. The public began to suffer a serious mortgage crisis [7]. As a result, the capital losses a nd lack of credit to the banking system, so that no banks willing to lend money unless borrower to pay high interest rate. The banks which involved in this business are worried about losing their money. However, Lehman Brother was still announced good quarterly results even had problems and other investment banks (e. g.JP Morgan Chase, Citibank) had losses. In January of 2008, Lehman Brother reported their earnings shown that highest income up to $4 billion and their capital just $30 billion [2]. At that time their stock price up to $65, but eight months later the price fell to $4 with more than $600 billion debt. Since 2008, Lehman’s stock price had fallen by 60%. Besides, Lehman Brothers had alternative assets about $40 billion such as hedge funds, private equity funds and real estate funds. In May, Lehman Brothers reported that losses in hedge funds but then said they are recovered [11].Because of Lehman’s total debt $613 billion, and then the negotiation with Barcl ays Bank and Bank of America about take over Lehman Brothers was failed on September 14. While at the same time the investment banks gave up to help Lehman Brothers, Lehman’s market value dropped dramatically, these fact forced Lehman Brothers to filed for bankruptcy protection from the U. S. Bankruptcy Court in Manhattan on September 15, 2008 [4]. After filed for bankruptcy, Lehman Brothers exchanged trading at the OTC (Over the Counter) market only $0. 05 per share.Lehman exercised put option to ensure holders could get profit when they buy the stocks as $0. 05 per share and sell for strike price [10]. When the news of the fourth largest bank Lehman Brothers went bankrupt came out, the dollar currency and the U. S. stock index futures was declined at the same time, this indicated that the New York stock market crash in the open market. In order to prevent the open market crash of Lehman Brothers, the U. S. Treasury and the Federal Reserve System made great effort on three d ays to save markets. The investment bank Barclays and Bank of America exited.The Britain's third largest bank Barclays decided to drop out after the government refused to provide financial guarantees to save Lehman Brothers. Then, the bank of America all announced exit the action. Because the government refused to help and no other support, Lehman Brothers final decided to file for bankruptcy protection caused by suffered serious financial crisis[6]. As we can see, there are many factors caused bankruptcy of Lehman Brothers, such as market changes and instability led to systematic risks, the internal problems and risks from Lehman Brothers.The internal problem is one of the most important factors to cause it collapse. As the fourth largest investment bank in the United States, Lehman Brothers more focused on the traditional investment business such as underwriting securities, mergers and acquisitions for a long term. With the rapid development of financial derivatives and fixed inco me products trading, Lehman Brothers strived to expand these businesses and achieved great success. The real estate and credit business develop rapidly after 2000, Lehman Brothers began to involve in these business as other banks [6].However, Lehman Brothers expanded too fast and even in the decline of real estate market in 2007, the commercial real estate bonds of Lehman Brothers still grown quickly. Thus, the rapid growth created more systematic risks for Lehman Brothers. In addition, Lehman Brothers was different from other investment banks like JP Morgan Chase, Bank of America because Lehman had less own capital and its capital adequacy ratio is too low [6]. In order to collected funds to expand business, Lehman had to rely on the bond market and bank lending market.The greater is the leverage ratio when the company borrowing more money from banks, but it has less equity capital. The profit is amplified by the leverage ratio when it makes money, but the loss is enlarging with th e leverage ratio when the company has loss. The lack of funds would be increase the risks for the company when it loss. Moreover, to analyzed the problem of Lehman Brothers’ collapse, it also should be related with the U. S. subprime mortgage crisis and recent financial turmoil intensified from the summer of 2007. In addition, it also considered about the problem of insolvent.Lehman Brother had more than $600 billion bank loans, $155 billion debt securities, and only $639 billion net assets [8]. Besides, the U. S. government took non-interventionism accelerated collapse of Lehman Brothers. As the U. S. government did not make any financial support or warranty to save Lehman Brothers, and leave the market accept the news of the Lehman bankruptcy. The government refused to guarantee Lehman Brothers directly caused many investors to exited, while the Barclays preferred to acquire part of Lehman’s investment business in the United States, this still not strong enough to sa ve Lehman Brothers.Furthermore, the financial markets turmoil around the world should be affect Lehman Brothers, and it also one of a reason affect many companies to left Lehman stocks and bonds whether the U. S. financial institutions or foreign enterprises. Since the market got the news of Lehman Brothers bankruptcy, the Dow Jones Index has dropped nearly 800 points [7]. In short, Lehman Brothers bankruptcy caused the devaluation of investment, cash flow problems and additional losses. Also Lehman financial crisis had a great influence on investors’ directions.Many investors worried about Lehman crisis would be exacerbated the financial crisis and the market prospect is gloomy. Therefore, the Wall Street investment bank Lehman Brothers was collapse in the financial tsunami of 2008. Then on March, 2012, it completed the bankruptcy reorganization and will be to repay debts to creditors. After that, the fourth largest investment bank of the United States has become a historica l. The bankruptcy of Lehman Brothers might impact the entire financial market, the investors worried about the outlook of the U. S. economic and the international oil rices continued to decline. And the investors also concerned that the demand of crude oil and other commodities is likely to fall under the shadow of global recession. At the same time, the risk aversion awareness prompted investors to sell commodities and high risk assets. The U. S. stocks sharply down and European stock markets also had a significant decline. The event of Lehman Brothers gave to the world economic recovery to cast more dark shadows in 2008. References [1] Lehman Brothers Collection. Harvard Business School. Baker Library. Retrieved from http://www. ibrary. hbs. edu/hc/lehman/history. html [2] Sean Hinton. Lehman Brothers (LEHMQ). Wikinvest. Retrieved from http://www. wikinvest. com/stock/Lehman_Brothers_%28LEHMQ%29 [3] Landon Thomas Jr. (July 23, 2003). Market Place; Lehman to Buy Neuberger Berman Fo r $2. 6 Billion. The New York Times. Retrieved from http://www. nytimes. com/2003/07/23/business/market-place-lehman-to-buy-neuberger-berman-for-2. 6-billion. html [4] Lehman Bros files for bankruptcy. (September 16, 2008). Retrieved from http://news. bbc. co. uk/2/hi/business/7615931. stm [5] Lehman Brothers Holdings, Inc.Spector Roseman Kodroff & Willis. Retrieved from http://www. srkw-law. com/areas-of-practice/international/lehman-brothers. html [6] Luigi Zingales. (October 2008). Causes and Effects of the Lehman Brothers Bankruptcy. Retrieved from http://www. scribd. com/doc/11096014/Causes-and-Effects-of-the-Lehman-Brothers-Bankruptcy [7] Lehman Brother. Retrieved from http://en. wikipedia. org/wiki/Lehman_Brothers [8] Kim Sarro & Justin Pak. (November 29, 2008). The Causes for the Collapse of Lehman Brothers Holdings Inc. Retrieved from http://www. articlesbase. om/business-articles/the-causes-for-the-collapse-of-lehman-brothers-holdings-inc-664202. html [9] Lehman Brothers: The last empire of wealth. (December 6, 2011). Retrieved from http://www. stockmarkettoday. cc/lehman-brothers-the-last-empire-of-wealth. html [10] What Happens To Options During Bankruptcy. Option Trading Pedia. Retrieved from http://www. optiontradingpedia. com/what_happens_to_options_during_bankruptcy. htm [11] Hedge funds post biggest losses since Lehman. (June 2010). Retrieved from http://connection. ebscohost. com/c/articles/52970726/hedge-funds-post-biggest-losses-since-lehman

Correction for Essay

Correction for Essay Correction for Essay Avery Anderson Period 3 November 2014 Family influences how people think and feel about the world around them, because people spend the most time with their family. In â€Å"By Any Other Name†, Santha Rau and her sister Premila went to the Anglo Indian day school in Zorinabad. They are exposed to British ways of thinking, which conflicts with the way their family taught them how to think about themselves and the world around them. This causes confusion and apathy in Santha. When Santha is given her new name Cynthia, she gets confused about who she is because her family already gave her a name. The teacher asks Santha to introduce her-self by saying her name in front of the class, she simply says â€Å"I don’t know† (Rau 36) and takes a seat. Since Santha was already taught by her mother the basics they were learning in class, she wasn’t really paying attention. She writes, â€Å"most of that morning I was bored †¦ the lessons were mostly concerned with reading and writing – things my mother had already taught me† (Rau 37). Santha saw herself as the identity that her family gave her as a kid. When that was changed by the British it caused confusion, because she lost sight of what she thought her identity was. Also her mom already taught her how to read and write, causing her to be bored because she already knew what was being taught. In â€Å"An Indian Father’s Plea†, Robert Lake is defending his son Wind-Wolf from being labeled as a slow learner. Wind-Wolf is not a slow learner but was taught the Cherokee way of viewing the world by his family. Wind-Wolf was taught differently by his family speaking things verbally. His dad expresses to the teacher that â€Å"he may have trouble writing his name on a piece

How to Rename or Define

How to Rename or Define How to Rename or Define How to Rename or Define By Mark Nichol When constructing a sentence in which a term or concept is described in other words or a meaning is given, use these guidelines for punctuating the parenthesis. When using namely, which establishes that one or more examples or names of a thing will be provided, or employing phrases that serve a similar purpose (such as â€Å"for example† and â€Å"that is†), always follow the word or phrase with a comma. The punctuation preceding the word or phrase depends on the structure of the sentence. (The abbreviations e.g. and i.e., representing Latin phrases equivalent to â€Å"for example† and â€Å"that is,† respectively, are discouraged in formal prose in favor of the English phrases except in parentheses or in notes; use the same surrounding punctuation for the abbreviations as for the phrases.) When what follows is a simple phrase and not an independent clause, precede namely and the like with an em dash to signal that one is transitioning from discussing something to providing examples about it: â€Å"Constitutional law defines the interrelationships between various branches of government within a state namely, the executive, the legislative, and the judicial.† Alternatively, enclose the additional information in parentheses: â€Å"I enjoy reading nineteenth-century historical adventure novels (for example, those by Sir Arthur Conan Doyle, Sir Walter Scott, and Robert Louis Stevenson).† If the word or phrase, and what follows, is an independent clause, start a new sentence or precede the word or phrase with a semicolon: â€Å"I agree with what you said. That is, I agree if I understand what you meant.† â€Å"I agree with what you said; that is, I agree if I understand what you meant.† An em dash may be used in place of the period or semicolon to signal an abrupt addition to the preceding statement, or use parentheses to represent an afterthought. Another option, in place of using namely, is to employ a colon, which among other purposes is used to indicate an expansion or explanation: â€Å"Constitutional law defines the interrelationships between various branches of government within a state: the executive, the legislative, and the judicial.† â€Å"For example,† â€Å"that is,† and similar phrases can be used following a colon or an em dash: â€Å"I enjoy reading nineteenth-century historical adventure novelists: Sir Arthur Conan Doyle, Sir Walter Scott, and Robert Louis Stevenson, for example.† â€Å"I enjoy reading nineteenth-century historical adventure novelists that is, writers like Sir Arthur Conan Doyle, Sir Walter Scott, and Robert Louis Stevenson.† (Either phrase can precede or follow the examples, but â€Å"for example† usually comes at the end and â€Å"that is† usually appears at the beginning.) Use of â€Å"in other words† as a transitional phrase follows these patterns (the particular method of punctuation depends on the context specific to a sentence): â€Å"We have insufficient funds to continue operating in other words, we are broke.† â€Å"We have insufficient funds to continue operating. In other words, we are broke.† â€Å"We have insufficient funds to continue operating; in other words, we are broke.† â€Å"We have insufficient funds to continue operating. (In other words, we are broke.)† One similar point about punctuation is how to provide a gloss, or a brief definition, as I’ve done in this sentence for the word gloss: Set the gloss off from the term with a pair of commas. Alternatively, enclose the gloss in parentheses, especially if the gloss is a translation: The word is chico (â€Å"boy,† â€Å"child,† or â€Å"small†). Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Style category, check our popular posts, or choose a related post below:Creative Writing 101Proved vs. ProvenGlimpse and Glance: Same or Different?

Speakers' Primary Motives Coursework Example | Topics and Well Written Essays - 750 words

Speakers' Primary Motives - Coursework Example As a sitcom episode, "Lucy and the Loving Cup," I Love Lucy can effectually be analyzed from Burke’s perception of dramatism. "Lucy and the Loving Cup," I Love Lucy is a favorite episode that utterly and significantly conveys the pentad as put forward by Burke. An analysis of this episode will outspokenly enable the comprehension of human philosophy and the motive behind a speaker’s acts and actions. Lucille Ball’s eyeballs were made into the decorative design on the cup so that she could somehow see and get a clear perception of the comedy that was unveiling around her. All the actions that Lucille Ball engages in are ostensibly motivated by the acrimony of characters around her. Her actions are also motivated by the symbols in and around her but language remain her paramount symbol. Her atrocious claustrophobia does not impede her from finding a way of wearing the loving cup. Outstandingly, most of the actions of the characters are motivated by the sheer fact that they want to hide their guilt while at the same time make the comedy continue and even make it more attention grabbing. Ricky’s disapproves Lucy’s new hat as a way of walloping or eluding the guilt that people could associate with the hat. As an escape strategy, Ricky’s makes fun of the hat as a way of dismissing and hiding her compassionate. Unquestionably, Ricky’s actions are inspired by guilt redemption and apparently reflect the ambiguity of substance that is predominant in the jesting. For instance, when Ricky discovers a cache of silverware and large amount of cash in a purse that was portentously owned by Lucy, she jumps onto the inordinate conclusion that Lucy was a kleptomaniac oblivious of the fact that Lucy was accumulating the items for a club bazaar. This was a tranquil and quick way of misapprehending Lucy and shifting the blame. Additionally, when Ricky tells Ethel, â€Å"Oh, now, Ethel, I know that Fred is a

Receiving A Telephone Call From The Security Guard. Company's Security Essay

Receiving A Telephone Call From The Security Guard. Company's Security Issues - Essay Example I'll further ask the security guard to produce a list of those who entered the locker room and list of those who operated their lockers in last twenty four hours. The Security guard will be asked to call upon the in-charge of department handling cameras and equipments, the in charge will be requested to figure out if he had any clue regarding loss of the cameras. If yes, the main in-charge will be requested to report the exact timings of the loss. The security department will be asked to ascertain the list of those who visited the equipment department, and inquire about their purpose of visit, the frequency of visits has to be noted down. Upon reaching the location, I'll inspect the data gathered by the security guard. Every present employee, including the security officials, will be handed over a page, to give a brief description of their entire working day; the respective pages will then be handed over to the in-charge of the department for confirmation and verification. In the meantime, I'll develop a personal interaction with Randeep, listen to his part of the story, the team leader of his department will be requested to give me a highlight about employee's past record and activities. Randeep will be asked to provide the exact timings of when did he operated his locker last time, and why should he be considered innocent of the charges. Of course I will not consider Randeep to be the culprit, because if he had to steal it, he would not have been fool enough to place those cameras into his locker, that are regularly inspected. Randeep is either too stupid to make such robbery, or he is innocent. I'll inform the company's management about the incident, and will inform him about the steps taken. I'll seek his guidance, if he wanted crime forces to intervene, and conduct the inquiry, or wait for the outcome of the steps initiated by my authority as Human Resource Manager. The company's management guidance will be requested with reference to ordering immediate termination letter to the employees found guilty of charges. The company's management will be informed as per their convenience, before the next working day commence. What do you think has happened After listening to the employee's version, and receiving briefing by the team leader. I'll ask my deputy to interact with Phil. Phil will be asked verbally to ascertain all that he has written on the paper, he will asked to proof that he has no connection with the charges, such that neither he plotted the event, nor he supported Randeep for his action. I'll ask my deputy to not only target Phil, but target some other individuals, including staff in the security, because it was mainly a lapse from their side as well. I would have personally considered Randeep to be the culprit, but the reason for not doing is that because the crime committed or impose upon Randeep has emerged out during the period when the company is likely to announce the nomination of Randeep for the position of Team Leader. An employee who is so dedicated and sincere towards his task, who understands that he will be promoted soon, is not likely to commit such crime, perhaps Randeep would have received better opportunities to steal after his promotion. I will certainly have different versions related to the incident, 1. Either Randeep has stolen the camera, to gather money, because he has been always complaining shortage of finances after he separated. 2. Either Phil has committed this folly, because he wanted to damage the image of Randeep, as the company planned to announce the suitable

Minimum Wage is a frequent topic of political debate. Analyze the pros Essay

Minimum Wage is a frequent topic of political debate. Analyze the pros and cons of such a policy using the relevant theoretical - Essay Example This made it a requirement of all states to set this as their minimum wage limit but this does not make it mandatory because some states exhibit variations of this set minimum. Some states, like California, have higher limits of this wage, which is at $8.00 while others, like Georgia, have wage limits below that federal limit at $5.15 per hour. These differences are made possible, by the municipal and state laws, which make it possible, for individual states to set their own minimum wage limits by exercising their right to enact their own by laws. This enables them to determine the limit of minimum wage, with respect to the economic potential of that a given state because it would not make sense to match the minimum wage with a rich state in terms of resources. This is an analytical discussion about the advantages and disadvantages of the minimum wage policy in the United States of America using a theoretical construct approach. Minimum wage from an economists view is disadvantageous to the market system of demand and supply. This is because when the minimum wage is raised the number of people vying for that job position increase, but the employer’s willingness to offer the position decreases because it is an increase in expenses in terms of salaries. In this scenario, employers would rather delegate the duties to be filled, by the new position to existing employees, than offering the job position. On the other hand, if the minimum wage were reduced, it would give employers an opportunity to create more job opportunities in organizations because they can afford to do so. This would depend on the amount of the wage set because a minimum wage of $1 per hour would not attract anyone, but student workers could consider a $4 per hour. Setting up the minimum wage law disrupted the functioning of supply and demand system because it dictates what employers should pay, instead of letting the two factors standardize the field on their own. Market factors of demand and supply govern the number and type of jobs available along what each job category would pay (Schmidt, 19). Increasing the minimum wage deprives a group of young Americans the much needed life lessons, which can be acquired when one works minimum wage job. This is because these jobs are popular with interns, workers in training and students, which help them, learn early in life how to handle money and relate with people in different circumstances (Schmidt, 16). They instill the values of hard work, responsibility and hard work early in their lives and motivate them to aspire to go to college and acquire advanced skills, which can enable them get better paying jobs in the future. Raising the minimum wage reduces the number of these types of jobs because employers will not be willing to offer these job positions because of increased salaries. This will translate to the emergence of a generation of Americans who have no value for hard work and responsibility, which would be detrimen tal to the economy of the country. It means that most of the American society in the future will lack a driving force that is essential in inculcating work ethics that are vital to a vibrant economy characterized by a work force that knows and understands the benefits of hard work. An increase in the minimum wage will result in a decrease of job opportunities that offer invaluable experience that is a prerequisite in almost all well paying and stimulating jobs in America. New entrants into

3-Methylglutaconic Aciduria Research

3-Methylglutaconic Aciduria Research A distinct type of 3-methylglutaconic aciduria due to a mutation in the Translocase of Inner Mitochondrial Membrane 50 (TIMM50) gene Abstract BACKGROUND: 3-methylglutaconic aciduria biochemically characterized by increased urinary excretion of 3-methylglutaconic acid result from defective leucine metabolism and disorders affecting mitochondrial function though in many cases the cause remains unknown. Recently mutations in mitochondrial TIMM50 gene has been reported in four patients from two unrelated families. We report additional mutations in TIMM50 gene in 6 individuals from two unrelated consanguineous families with a distinctive type of 3-methylglutaconic aciduria. METHODS:Â  We report on three patients of South Asian ancestry with intractable epilepsy, microcephaly, developmental delay, visual deficit spastic quadriplegia and three Caucasian patients of eastern European origin with intellectual disability with or without seizure. Metabolic testing revealed mild lactic acidosis and excretion of large amount of 3-methylglutaconic acid in urine in all patients. Full exome sequencing was performed using genomic DNA isolated from one surviving patient, two healthy siblings and both parents of South Asian family. Exome sequencing was also performed for Caucasian patients of eastern European origin. RESULTS:Â  Exome sequencing identified two homozygous mutation Gly372Ser and Iso392Thr mutations in the gene TIMM50. There were no other candidate alterations in exome that could explain the phenotype in the proband. The mutations are located in the conserved C-terminal domain of the Tim50 protein that interacts with the N-terminal domain of the Tim23 protein in the intermembrane space and regulates mitochondrial protein import of presequence-containing polypeptides Both parents are heterozygous. CONCLUSION: Given the phenotypic similarilty of the patients from two unrelated families and an earlier report of mutations in additional family, we conclude that TIMM50 gene mutation results in a novel mitochondrial disorder with 3-methyl glutaconic aciduria. INTRODUCTION 3-methylglutaconic aciduria (MGCA), an increase in urinary 3-methylglutaconic acid or 3-methylglutaric acid, can be a nonspecific finding in mitochondrial disorders, organic aciduria, urea cycles disease, neuromuscular disorders. but is a consistent abnormality of 3-methylglutaconyl-CoA hydratase deficiency and patients with mutations in TAZ, SERAC1, OPA3, DNAJC19 and TMEM70 gene1. These genes all encode mitochondrial membrane or membrane related proteins. In 3-methylglutaconyl-CoA hydratase deficiency due to mutation in AUH gene , 3-methylglutaconic acid derives from 3-methylglutaconyl CoA (3MG CoA), an intermediate in leucine catabolism1. It has been proposed that in other disorders, 3-methylglutaconic acid derives from aberrant isoprenoid shunting from cytosol to mitochondria via mevalonate pathway or redirection of mitochondrial acetyl CoA toward production of 3MGA due to an increase in the intra-mitochondrial NADH/NAD+ ratio resulting from mutation induced impairment in electron transport chain or Kreb cycle function 2. Examples of mitochondrial include Barth syndrome, a cardioskeletal myopathy with neutropenia, abnormal mitochondria and MGCA. Barth syndrome is caused by X-linked recessive mutations in the TAZ gene which encodes the mitochondrial membrane localized transacylase involved in the maturation of cardiolipin. Autosomal recessive mutations in the OPA3 gene (OMIM: 606580), the mouse ortholog of which encodes a mitochondrial inner membrane protein of unknown function, cause MGCA3 (OMIM: 258501), a neuroopthalmologic syndrome characterized by early-onset bilateral optic atrophy and later-onset spasticity, extrapyramidal dysfunction and cognitive deficit. MGCA5 (OMIM: 610198) is yet another form of MGCA caused by autosomal recessive mutations in the DNAJC19 gene (OMIM: 608977) and in addition to increased urinary excretion of 3-methylglutaconic acid, patients present with infancy or childhood onset dilated cardiomyopathy, microcytic anemia, mild muscle weakness and ataxia. Many patients die of cardiac failure. The DNAJC19 gene encodes the human homolog of the yeast Tim14 which is a part of the Tim23 mitochondrial protein import machinery and hasbeen shown to interact with the mtHsp70 in an ATP-dependent manner to regulate Tim23 function (Davey, 2006). WE report a distinct type of 3-methylglutaconic aciduria resulting from a mutation in mitochondrial TIMM50 gene in 3 sibs from a consanguineous family. We initially reported these xases in abstract form. Recently two different mutations in mitochondrial TIMM50 gene have been reported in four patients with 3 methylglutaconic aciduria, epilepsy, severe intellectual disability and lactic acidosis. Subjects Family 1 Family 1 has three affected sibs of South Asian ancestry with intractable epilepsy, microcephaly, developmental delay, visual deficit spastic quadriplegia. Two affected sibs died unexpectedly when they were visiting families in a remote area of a South Asian country. Metabolic testing had revealed large amount of 3-methylglutaconic acid in urine in all three affected sibs. The patients have a healthy brother and a healthy sister. Mother and father are first cousins. Detailed clinical history, imaging, EEG and metabolic testing were obtained for all affected persons. Full exome sequencing was performed using genomic DNA isolated from one surviving patient, two healthy siblings and both parents. Patient IV-1. Patient IV-1 was the first born child of the parents and was born at 36 weeks gestation after a normal pregnancy and delivery. Her weight at birth was 1.99 kg. Her weight, height and head circumference were always below 5th centile. She also had asthma and frequent episodes of pneumonia presumably due to aspiration, but the family refused G-tube placement. She was severely delayed. She never sat, stand or spoke. She has poor head control, truncal hypotonia but very brisk tendon jerks and sustained clonus. Funduscopy revealed bilateral optic atrophy. She developed seizures at 1 year of age. EEG revealed multifocal spikes arising from both hemispheres. She was treated with phenobarbital and Zonegran but family was noncompliant with medications. She continued to have daily myoclonic jerks. MRI at 2.5 and 5 years of age showed increased T2 signal in basal ganglia and periventricular white matter, brain atrophy, prominent ventricle, increased extraxial fluid. Normal liver en zymes and blood count, normal blood and CSF glucose and a serum ammonia of 21. Several serum lactate levels were mildly elevated. Lactate 2.8, 4.5 (Pyruvate 0.23), 5.4 (normal 0.7 to 2.1) Lactate to pyruvate ratio 20:1. Urine organic acid analysis revealed very high lactic acid, 3-methylglutaconic acid, and 3-methylglutaric acid. Muscle biopsy revealed only scattered atrophic muscle fibers on electron microscopy. Respiratory chain enzyme activities were within normal limits. She died at 7.5 years of age apparently due to complications from an infection while she was visiting families in a remote area of a South Asian country. Patient IV-4 was twin A born at 36 weeks gestation after an uncomplicated twin pregnancy. Her weight, height and head circumference were always below 5th centile. She was severely delayed. She never sat, stand or spoke. She has poor head control, truncal hypotonia but very increased reflexes and spasticity in the limbs. At nine-month-of age, she started to experience several episodes of eye fluttering and body jerking. Her EEG reved slow background, poor sleep architecture and frequent multifocal spike and sharp wave activities coming from both the left and right hemispheres. Her seizures were treated with Zonegran and was poorly controlled but parents refused more aggressive treatment of seizures. Metabolic testing revealed mild elevation of lactate and moderate increase of 3 methylglutaconic, 3 methylglutaric acids in urine. A brain MRI at 11-month-of age revealed diffuse volume loss supratentorially with prominent sulci and extraaxial fluid spaces, mild enlargement of the ventricl es and patchy signal abnormalities in the basal ganglia bilaterally, especially involving the caudate nuclei and putamen. On spectroscopy with voxel placed in the right basal ganglia with short and long TE, there was a lactate peak which inverted on long TE spectrum. Also, the NAA peak was low with NAA to creatinine being 1.15 on short echo and 1.29 on long echo spectrum. Also, the choline was elevated with choline/creatine ratio being 1.00 on short echo and 1.41 on long echo images. She died at 1.5 years of age apparently due to complications of an infection while she was visiting families in a remote area of a South Asian country. Patient IV-5 is a 13 year old female of South Asian ancestry, with 3-methylglutaconic aciduria intractable epilepsy, microcephaly, developmental delay, visual deficit and spastic quadriplegia. She was born at 36 weeks gestation after an uncomplicated twin pregnancy. She was twin B and stayed in NICU for 18 days for feeding issues. Her weight was 1.4 kg and she was not intubated. Patient first presented with seizures at 3 months of age with eyelid fluter and jerking of extremities. Her initial EEG revealed multifoal spikes. Initial biochemical evaluation revealed normal serum and CSF glucose, normal ammonia and liver enzymes. Serum lactate and CSF lactate 4.24 mmol were mildly elevated . Lactate was 2.7. Ammonia 25. Serum amino increased alanine 43.6 micromol/dl (9.9-34.5). Csf lactate 4.24 mmol. CSF alanine 7 micromol/dl (0.6 -4.7). There were also mild elevations of serum and CSF valine, leucine, isoleucine and alanine and lysine. Urine organic analysis revealed moderate increase of 3 methylglutaconic, 3 methylglutaric, glutaric, adipic, suberic, and sebacic acids. MRI of brain at 11 months of age revealed severe atrophic changes involving gray and white matter, predominantly of the cerebrum. Grossly abnormal signal is seen in the basal ganglia, particularly the caudate nucleus and the putamen with relative sparing of the globus pallidus and thalamus. A recent MRI (at age 13 years) reveals severe but stable atrophic changes of the gray and white matter of the supra and infratentorial brain, stable white matter changes of the putamen, caudate nucleus and periventricular white matter, Scattered diffusion restriction in the retrotrigonal white matter, compatible with active demyelination and atrophic changes of the optic nerves. Her seizures were treated with with Keppra, Lamictal, Zonegran and Onfi. She also receives carnitine. She continues to have brief episodes of whole body stiffening each week, but the family was also not very compliant with medications. He r current EEG shows slow background for age, poorly formed sleep spindles indicatvie of diffuse neuronal dysfunction, frequent multifocal interictal spike and wave suggests increased risk of seizures arising from multiple foci and hypsarrhythmia in sleep . She has failure to thrive despite G-tube feeding. At 12 years of age, G-tube was placed due to history of aspirations. Height, weight and head circumference below 5th centile. She is severely delayed. She is nonverbal and never learned to sit independently, stand or walk. She recognizes family members, responds to their voice and looks and smiles at them. Her fundoscopy shows mild optic atrophy. She has bilateral esotropia and dysconjugate gaze. She has poor head control and truncal hypotonia, but her limbs are spastic and her tendon reflexes are very brisk. Family 2 Patient V:1 was the first son of Caucasian consanguineous parents (IV:4 and IV:5) of Eastern European origin. Within the context of an organic acid and amino acid study in young and adult subjects with non-syndromic developmental delay and intellectual disability, he was investigated at the age of 17 years and presented with a developmental language disorder (involving semantic, syntactic, and pragmatic components of the linguistic system), emotional and communicative problems (fearful, aggressive, and loner), and hyperactivity. On neuropsychological testing he showed a short attention span. The child was born at term after an uneventful pregnancy and his birth weight was 2.9 kg. At 4 months of age he was affected by myoclonic jerks that were controlled by administration of valproic acid and lamotrigine. Developmental delay was observed starting from the middle of the first year of life, accompanied by decreased muscle tone. He could walk without support only at 6 years. At last medi cal exam, the patient showed a reduced muscle mass (height 148 cm, Z-score 3.43; weight 38 kg, Z-score 4.21; BMI 17.1 kg/m2, Z-score 2.02) and a head circumference of 51 cm (Z-score 2.76). Due to refusal of parents, no brain imaging studies could be performed. Fundoscopic examination was normal. Laboratory tests, including creatine phosphokinase (CPK), liver enzymes and plasma amino acids, were normal. The profile of urinary organic acids showed a large peak of 3-methylglutaconic acid (113 mmol/mol creatine) and a slightly increased level of 3-methylglutaric acid (17 mmol/mol creatinine). Patient V:3 was the younger brother of V:1, the third child of IV:4 and IV:5. He was investigated at the age of 11 years and presented with a clinical phenotype (developmental delay and intellectual and behavioral disorder) similar to that of his brother. The pregnancy and early postnatal course was unremarkable and birth weight was 3.1 kg. At 3 months he received valproic acid and lamotrigine to control tonic seizures with sudden stiffening movements of arms and legs. The boy walked independently at 4 years. When he was 9 years, his growing parameters were: height 119 cm (Z-score 2.47), weight 22 kg (Z-score 1.91), BMI 15.5 kg/m2 (Z-score 0.38), and head circumference 48 cm (Z-score 3.52). Neuropsychological exam revealed mental retardation and impaired communicative skills, including poor language abilities (few repetitive words with no sentences). Occasionally, the patient is aggressive. Ophthalmologic examination revealed left esotropia. High levels of 3-methylglutaconic acid (15 5 mmol/mol creatine) were identified in urine, together with smaller amounts of 3-methylglutaric acid (22 mmol/mol creatinine). Patient V:5 was the second son of consanguineous parents (IV:9 and IV:10) related to those of patients V:1 and V:3. The girl was delivered by cesarean section because of growth arrest at 37 week. The neonate showed no external malformations. Birth weight was 2.1 kg. In the following years, the clinical phenotype was characterized by delayed developmental milestones, nocturnal enuresis, severe cognitive impairment, speech retardation, and lack of communicative skills. Results of the electroencephalogram were normal. No brain imaging data are available. On a few occasions, levels of ammonia and lactic acid were found to be slightly elevated, but these results could not be confirmed by repeated blood analyses. Plasma levels of amino acids are within normal range. Fundoscopic examination was normal up to 7 years, but since then there is evidence of mild bilateral optic atrophy. Urine levels of of 3-methylglutaconic acid and 3-methylglutaric acid were 176 mmol/mol creatine and 29 mmol/mol creatinine, respectively. DISCUSSION Deleterious Nature of the TIMM50 gene alteration: TIMM50 NM_001001563 c.1114G>A p.G372S The p.G372S variant (also known as c.1114G>A), located in coding exon 9 of the TIMM50 gene, results from a G to A substitution at nucleotide position 1114. The glycine at codon 372 is replaced by serine, an amino acid with somewhat similar properties. The alteration is not observed in healthy cohorts: Based on data from the NHLBI Exome Sequencing Project (ESP), the TIMM50 c.1114G>A alteration was not observed among 6,503 individuals tested. Allele frequency data for this nucleotide position are not currently available from the 1000 Genomes Project and the alteration is not currently listed in the Database of Single Nucleotide Polymorphisms (dbSNP). Though some variants may appear to be rare due to database-specific ethnic underrepresentation, rare missense alleles commonly exhibit a deleterious effect on protein function (Kryukov, 2007; Tennessen, 2012). The altered amino acid is conserved throughout evolution: The G372 amino acid position is completely conserved in eukaryotes all th e way from the yeast Saccharomyces cerevisiae to humans (Mokranjac, 2003). The alteration is predicted deleterious by in silico models: The p.G372S alteration is predicted to be probably damaging and deleterious by PolyPhen and SIFT in silico analyses, respectively. The amino acid is located in a functionally important protein domain: The p.G372S alteration is located in the conserved C-terminal domain of the Tim50 protein that interacts with the N-terminal domain of the Tim23 protein in the inter membrane space and regulates mitochondrial protein import of presequence-containing polypeptides (Geissler, 2002; Yamamoto, 2002; Guo, 2004). The alteration cosegregated with disease in the family herein: Co-segregation analysis revealed that this alteration is present in a heterozygous form in the mother, father and brother, and absent in the sister. Based on the available evidence, the TIMM50 c.1114G>A (p.G372S) alteration is classified as a likely pathogenic mutation. The TIMM50 gene is not currently known to underlie Mendelian disease (aka clinically novel). The TIMM50 gene function is consistent with the probands clinical presentation: The Translocase of Inner Mitochondrial Membrane 50 (TIMM50) gene (OMIM: 607381) is located on human chromosome 19q13.2 and consists of 11 exons. It encodes the Tim50 protein, a 353 amino acid 40 kDA homolog of the yeast Tim50 protein that functions as an integral part of the mitochondrial Tim23 protein import machinery by linking protein translocation across the outer and inner mitochondrial membranes. This interaction was confirmed by the coprecipitation of Tim50 with an antibody against Tim23 (Geissler, 2002; Yamamoto, 2002; Guo, 2004). The authors further confirmed that the C-terminal domain of Tim50 is located in the inter-membrane space (IMS) where it stably binds to the segment of Tim23 that spans the IMS and regulates its function. Nuclear encoded mitochondrial proteins are synthesized in the cytosol and subsequently imported into the mitochondria through the function of translocators, the TOM complex of the outer mitochondrial membrane (OMM), and the Tim23 and Tim22 complexes of the inner mitochondrial membrane (IMM) (Jensen, 2002). While the Tim22 complex is involved in the transport and insertion of proteins lacking the presequence into the inner membrane, the Tim23 complex is required to process and insert presequence-containing precursor proteins. The IMM generates a proton motive force that is critical for cellular energy synthesis (Stock, 2000) and the permeability barrier of the IMM needs to be maintained during the transport of proteins through the pore-forming Tim23 protein associated with other IMM proteins such as Tim14 (human DNAJC19), Tim17, Tim21, Tim44 and Tim50. Using various yeast IMM protein mutants, Meinecke et al. (2006) demonstrated that tim17 and tim21 mutant mitochondria displayed membra ne potential values that were comparable to wild type mitochondria, whereas tim50 mutant mitochondria showed a drastic reduction of the membrane potential. Further functional studies revealed that the Tim23 channel is tightly regulated by Tim50 in its inactive state to maintain the IMM permeability barrier and is opened only when presequence-containing polypeptide chains need to be translocated into the mitochondrial matrix or the inter membrane space (IMS). Loss of Tim50 function in yeast led to cellular growth arrest and reduced cell viability (Mokranjac, 2003). Knockdown to Tim50 expression in cultured human cells using RNA mediated interference resulted in an increase in the release of cytochrome c and apoptosis in response to cell death stimuli (Guo, 2004). A 50 kDa isoform of the human mitochondrial TIM50, TIM50a, consisting of 456 amino acids has been found to localize in nuclear speckles, specifically in the Cajal bodies, and interact with small nuclear ribonuclear proteins (snRNPs), the coilin protein and the Survival of Motor Neurons (SMN) protein (Xu, 2005) which has been implicated in Spinal Muscular Atrophy (SMA). The protein sequences of the mitochondrial TIM50 and the nuclear TIM50a are identical with the exception of additional 103 amino acids at the N-terminal of TIM50a that are the result of an alternative translational start sequence. This additional N-terminal sequence in TIM50a is thought to contain a putative nuclear localization sequence that allows the Tim50a isoform to display a nucleus specific localization. Based on their results, Xu et al. hypothesized that Tim50a might be involved in the regulation of snRNP biogenesis and possibly the function of the nuclear SMN protein encoded by the SMN1 gene. One of our patien ts had mulsle biopsy. Although there were atrophic changes, no neuropthic pattern was seen. Reference List (1) Wortmann SB, Kluijtmans LA, Rodenburg RJ et al. 3-Methylglutaconic acidurialessons from 50 genes and 977 patients. J Inherit Metab Dis 2013;36:913-921. (2) Ikon N, Ryan RO. On the origin of 3-methylglutaconic acid in disorders of mitochondrial energy metabolism. J Inherit Metab Dis 2016;39:749-756. Legends Legend to Figure 1 Five-generations pedigree of the family with mild 3-methylglutaconic aciduria in which the TIMM50 p.(Ile293Thr) was identified. Subjects V:1, V:3, and V:5 (filled symbols) are patients suffering from intellectual disability and increased urinary excretion of 3-methylglutaconic acid. They are born to consanguineous parents and homozygous for the TIMM50 c.1011T>C mutation predicting the replacement of isoleucine 293 with threonine in the encoded protein. The mutation was inherited by a common ancestor (either I:1 or I:2) and has been identified in the heterozygous state in the clinically and biochemically unaffected subjects III:3, III:4, III:9, IV:2, IV:4; IV:5; IV:9, IV:10, and V:2.